NUBPL-depleted cells were observed to have an abnormal sub complex of proteins normally found in the membrane arm of complex I . A decrease in the presence of complex I subunit proteins, NDUFS1, NDUFV1, NDUFS3, and NDUFA13, indicated a failure of normal complex I assembly.
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A topological version of Zariski's main theorem says that if " x " is a ( closed ) point of a normal complex variety it is unibranch; in other words there are arbitrarily small neighborhoods " U " of " x " such that the set of non-singular points of " U " is connected.
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